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The second generation antihistamines have no central action, and are used only for treatment of allergic reactions. Cetirizine (Zyrtec) is a piperazine derivative, and has a slight sedative effect.Loratidine (Claritin) and fexofenadine (Allegra) are members of the piperadine class and are essentially non-sedating.H3 receptor antagonists could provide new treatment options for sleep disorders, weight loss, neuropathic pain, obesity, movement disorders, schizophrenia, attention deficit disorders, and Alzheimer’s dementia, while the development of antagonists for H4 receptors may lead to new treatment options for autoimmune inflammatory diseases.1,2 The first H1 sedating antihistamines have been available for more than 60 years and were synthesized based on a chemical structure similar to that used to develop cholinergic muscarinic antagonists, tranquilizers, and antihypertensive agents.These antihistamines have low receptor specificity and interact with both peripheral and central histamine receptors and readily cross the blood-brain barrier.These include the first-generation H1 antagonists, or sedating antihistamines (eg, diphenhydramine, chlorpheniramine), and second-generation H1 receptor blockers, or nonsedating antihistamines (eg, loratadine, cetirizine).First-generation antihistamines are widely available without a prescription and commonly used to treat allergic symptoms, including rhinitis, conjunctivitis, pruritus, eczema, urticaria, and anaphylactic reactions.If an antihistamine fails to provide adequate relief, switch to a drug from a different chemical class.

sedating antihistamines effect is related to-13sedating antihistamines effect is related to-25sedating antihistamines effect is related to-66

Some of the other adverse effects are chest tightness; wheezing; nasal stuffiness; dry mouth, nose and throat; sore throat; respiratory depression; sneezing; and a burning sensation in the nose.

systemic, topical or inhaled drugs that antagonize histamine and control allergies, e.g.

hayfever (seasonal rhinitis), drug allergies, urticaria (induced by insect bites); injected antihistamine (chlorphenamine) is used as an adjunct to adrenaline in the treatment of anaphylaxis and angioedema; modern antihistamines (e.g.

Additional effects vary with the individual drug used.

Several of the older drugs, called first-generation antihistamines, bind non-selectively to H receptors in the central nervous system as well as to peripheral receptors, and can produce sedation, inhibition of nausea and vomiting, and reduction of motion sickness.

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