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However, like any pharmaceutical product, no vaccine is completely safe or completely effective.While almost all known vaccine adverse events are minor and self-limited, some vaccines have been associated with very rare but serious health effects.This led to the National Childhood Vaccine Injury Act which is discussed in this chapter.Despite high national vaccination coverage rates, there are areas of low coverage that allow outbreaks of vaccine-preventable diseases to occur, many due to concerns about vaccine safety leading parents to refuse or delay their children’s immunizations.HMD convened the Committee on Assessment of Studies of Health Outcomes Related to the Recommended Childhood Immunization Schedule to conduct an independent evaluation of the safety of the childhood immunization schedule.The HMD report, “The Childhood Immunization Schedule and Safety” was issued on January 16, 2013.The IOM Committee used peer-reviewed literature to review eight vaccines given to children or adults: The findings indicate that these vaccines are very safe and that serious adverse events are quite rare.The HMD has conducted two similar extensive reviews in the past.

Vaccination is among the most significant public health success stories of all time.

Adding to public concern about vaccines is the fact that immunization is mandated by many state and local school entry requirements.

Because of this widespread use, safety problems with vaccines can have a potential impact on large numbers of persons.

The Committee also reconfirmed a finding [PDF - 631 KB] of the National Vaccine Advisory Committee (NVAC) that said conducting a study requiring some children to receive fewer vaccines than recommended, as would be needed for a randomized controlled trial, would be unethical.

Read the full report HHS charged the HMD with providing a thorough review of the current medical and scientific evidence on vaccines and vaccine adverse events.

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